This book constitutes the refereed proceedings of the 5th International Symposium on
Bioinformatics Research and Applications ISBRA 2009 held in Fort Lauderdale FL USA in May
2009. The 26 revised full papers presented together four invited papers were carefully reviewed
and selected from a total of 55 submissions. The papers cover a wide range of topics including
clustering and classification gene expression analysis gene networks genome analysis motif
finding pathways protein structure prediction protein domain interactions phylogenetics
and software tools.