The two-volume set LNCS 5601 and LNCS 5602 constitutes the refereed proceedings of the Third
International Work-Conference on the Interplay between Natural and Artificial Computation
IWINAC 2009 held in Santiago de Compostela Spain in June 2009. The 108 revised papers
presented are thematically divided into two volumes. The first volume includes papers relating
the most recent collaborations with Professor Mira and contributions mainly related with
theoretical conceptual and methodological aspects linking AI and knowledge engineering with
neurophysiology clinics and cognition. The second volume contains all the contributions
connected with biologically inspired methods and techniques for solving AI and knowledge
engineering problems in different application domains.