This book constitutes the refeered proceedings of the 21st International Conference on
Information Processing in Medical Imaging IPMI 2009 held in Williamsburg VA USA in July
2009 The 26 revised full papers and 33 revised poster papers presented were carefully reviewed
and selected from 150 submissions. The papers are organized in topical sections on diffusion
imaging PET imaging image registration functional networks space curves tractography
microscopy exploratory analyses features and detection image guided surgery shape analysis
motion and segmentation and validation.