Stress high blood pressure smoking pollution fast foods overweight excessive travelling
surgery less movement are common features in our modern life. These features are risky for
blood clotting disorders. According to WHO over 29% of the total mortalities worldwide are due
to thrombosis. By the year 2020 cardiovascular diseases (CVDs) may cause an estimated 25
million deaths per year thus antithrombotic therapy is of great interest. The available
thrombolytic agents such as urokinase are highly expensive antigenic quite unspecific
pyretogenic and hemorrhagenic. Therefore the production of fibrinolysing enzymes which
rapidly dissolute thrombi within the vascular tree without the detriments by microorganisms
as described in this book is the desirable aim of today's research.
