Prostate cancer is by far the most common cancer in men and the second leading cause of death
due to cancer. It comprises a mixed group of tumours displaying varying clinical behaviour:
while some have a very aggressive course others are rather indolent. Prevention of prostate
cancer and discrimination between aggressive and indolent forms are important clinical goals
and the acquisition of significant new evidence on means of achieving these aims makes this
book particularly timely. A wide range of topics are covered by leading authorities in the
field. The biology and natural history of prostate cancer are reviewed and the role of
lifestyle and dietary factors assessed. Detailed attention is paid to risk prediction
biomarkers and to the role of novel high-throughput nucleic acid-based technologies in
improving risk prediction and thereby allowing tailored approaches to cancer prevention.
Potential means of chemoprevention of prostate cancer are also reviewed in depth covering the
very positive new data on the impact of aspirin as well as evidence regarding 5a-reductase
inhibitors DFMO and lycopene. Guidance is provided on the differentiation of aggressive from
indolent disease and the policy and research implications of recent findings are examined. This
book will be of interest to both clinicians and researchers.
