This work presents methods to advance electrophysiological simulations of intracardiac
electrograms (IEGM). An experimental setup is introduced which combines electrical
measurements of extracellular potentials with a method for optical acquisition of the
transmembrane voltage in-vitro. Thereby intracardiac electrograms can be recorded under
defined conditions. Using experimental and clinical signals detailed simulations of IEGMs are
parametrized which can support clinical diagnosis.
