Quality-assured local and regional hyperthermia procedures have been proven to enhance the
clinical benefits of oncological standard treatments in several clinical settings without a
significant increase in late toxicity. This makes hyperthermia an attractive sensitizer for
both radiotherapy and chemotherapy. During the past decade clinical evidence on the beneficial
use of additive local and regional hyperthermia procedures as part of multimodality treatment
approaches for several malignant diseases has increased significantly. Today hyperthermia
plays a role in the treatment of chest wall recurrences after breast cancer locally advanced
cervical cancer locally advanced and recurrent rectal cancer high risk soft tissue sarcoma
anal carcinoma and bladder cancer. It is no longer a question whether hyperthermia is an
effective oncological treatment at all. Technical improvements in hyperthermia treatment
quality assurance and delivery standards were summarized by a dedicated team of physicists
technicians and clinicians. This booklet is dedicated to the interested reader without any
expertise in local and regional hyperthermia. It is designed to provide instant access with a
focus on current and upcoming clinical research.
