ECG recordings provide diagnostic relevant information on the de- and repolarisation sequences
of the heart. A modification of the repolarisation sequence is assumed to cause Torsades de
Pointes. Especially drug induced effects on the repolarisation processes are in focus since
some non-cardiac drugs have been associated with sudden cardiac death in the 1990s. The
analysis of the ventricular repolarisation using a set of parameters depicting the morphology
of the T-wave is introduced in this work. Therefore new methods of fully automatic
patient-specific QRS detection beat classification and precise T-wave delineation are
presented. Using these methods medical studies are investigated regarding the modification of
the T-wave by different compounds. Also the impact of the heart rate on the morphology of the
T-wave is part of this research. The reliable identification of ventricular ectopic beats
allows an analysis of the influence of these beats on subsequent heart beats. It turned out
that the morphology of subsequent heart beats can significantly be changed. This might give new
information on the proarrythmical risk of ventricular ectopic beats.
