The present study was aimed at synthesizing isatin-5-sulphonamide derivatives are prepared by
chlorosulphonation of isatin to prepare isatin-5-sulphonic acid chloride and it is subjected to
reaction with different amines or anilines to form respective sulphonamide derivatives. The new
compounds were characterized based on spectral (FT-IR NMR and Mass) analysis. All the test
compounds showed CNS depression while studying the gross behavioral changes. All the test
compounds exhibited reduction in locomotor activity. Compound IIIf (R = p-toluidino) showed
more reduction in the locomotor activity among all the test compounds. Compounds IIId IIIc
IIIb IIIa were next in the order of reduction of locomotor activity. The compounds were
evaluated for anticonvulsant activity against maximum electric shock induced and
Pentylenetetrazol (PTZ) induced seizures in mice using phenytoin as a standard.
