This book comprises seven chapters. In chapter 1 an overview of chemistry biological functions
and literature studies of hydroxamic acids (HA) and its isosteres is presented. The principles
of quantum mechanics underlying the computational methods employed to study HAs are given in
brief. Chapter 2 describes intra- and intermolecular H-bonding interactions between
formohydoxamic acid (FHA) and single water molecule and the dimerization among the isomeric
forms. Chapter 3 involves the comparative study of H-bonding abilities of thioformohydoxamic
acid (TFHA) and FHA. The deprotonation enthalpies of different sites of FHA and TFHA probable
pathways for interconversion among anions and their H-bonding with water are explored in
chapter 4. The Effect of aqueous medium on deprotonation by using solvation methods is also
discussed. Further insight into H-bonded aggregates and dimers of HAs is gained through the
analysis of calculated stabilization energies and their comparison to similar H-bonded
functionalities. The reasons behind the H-bond cooperativity in the aggregates and dimers are
explored in chapter 5. Chapter 6 deals with the study of properties of formylphosphinous acid
(FPA) isostere of FHA and a comparative study is carried out. In chapter 7 the aggregation of
the most stable keto and enol conformer of FHA and TFHA with five amino acid side chain groups
occurring at active sites of enzymes is studied.
