The life expectancy of liver cirrhosis patients drastically worsens with decompensation. In
this work a clinical score was developed to identify patients at high risk for decompensation
enabling targeted treatment. Furthermore to facilitate treatment and drug development for
liver cirrhosis patients a PBPK framework for liver cirrhosis was developed. The presented
work provides two tools for treatment optimization of liver cirrhosis patients potentially
improving patient health in the future.
