This book deals with the essential factors in the personalization of treatment for primary
breast cancer. These include host issues lymph node surgery radiation therapy and
preoperative systemic treatment requiring specialized knowledge multidisciplinary care
experience techniques and research. Locoregional treatment in conjunction with systemic
treatments is another important factor with options for local therapy significantly affected
by genetic BRCA mutation. Axillary treatment issues have become top priorities in recent
primary breast cancer care and these are highlighted in the book's presentation of
technological advances in lymph node mapping and diagnosis axillary clearance in patients with
nodal metastasis and the role of axillary surgery. Attention is also given to locoregional
treatment after preoperative systemic therapy. Because therapeutic impact differs depending
upon biological characteristics such as tumor subtype local therapy should be based both on
tumor biology and on therapeutic response in parallel. Associated translational research and
mathematical prediction tools such as nomograms also are introduced. This book provides the
essence of primary breast cancer care particularly its individualization with novel
therapeutic concepts and strategies and will greatly benefit physicians and clinical
investigators in breast cancer institutions.
