This book provides essential information on the epidemiology molecular and genetic features
anti-CCR4 antibody therapy and a nationwide study of transplantation on human T-leukemia virus
type-I (HTLV-1) and adult T-cell leukemia lymphoma (ATL). This rare but important disease has
restricted endemic areas and distinct clinical features such as a high frequency of
hypercalcemia strong predisposition to infection and poor response to chemotherapy aspects
which set ATL apart from other types of non-Hodgkin lymphoma. Given the small number of
patients enrollment in clinical trials has not been feasible and establishing treatment
standard has been difficult but new evidence such as results of nationwide studies on
transplantation have shown new insights and potential treatments. Based on recent evidence
the book presents new treatment methods for ATL and infection prevention of HTLV-1 enabling
clinicians researchers and post-docs specializing in hematology and virology to gain a
valuable overview of the disease.
