This book explores the major cytokines such as IL-1 and IFN-¿ with respect to the regulation
of their gene expression and protein production in specific immune cell types. It discusses
both healthy physiological settings and in pathological situations in which the expression of
some cytokines could be dysregulated resulting in either immunodeficiency or exacerbated
inflammatory sequelae in animal models as well as in human patients. Cytokines are important
regulators of immune responses that require the highly coordinated participation and
communication of multiple cell types. The expression of cytokines by various producer cell
types is therefore carefully regulated in response to environmental cues at multiple levels:
transcription translation and posttranslational modification. Presenting cutting-edge advances
in our understanding of the regulation of cytokine expression this book is a valuable resource
for anyone involved or interested in immune regulation.
