This book in two volumes focuses on contemporary issues and dilemmas in relation to
depression. The aim is to equip readers with an up-to-date understanding of the clinical and
neurobiological underpinnings of depression and their relation to clinical manifestations and
the development of more effective treatments. This first volume is devoted specifically to
biomedical and neurobiological issues. Detailed information is presented on a wide range of
topics including genetics molecular and cellular biology and aspects at the neural circuit
and multicellular system levels. Readers will gain a deeper appreciation of the factors and
interactions underlying individual variation in responsiveness to stress and vulnerability to
depression as well as a clear understanding of potential treatment targets and causes of
treatment resistance based on the latest research. A concluding section considers progress
towards precision psychiatry and gender and cultural differences in depression. The companion
volume is dedicated to clinical and management issues in depression. Understanding Depression
will be an excellent source of information for both researchers and practitioners in the field.
