This textbook summarizes the state of the art in the management of locally advanced and
metastatic prostate cancer with the aim of providing the knowledge required for optimal
treatment decision making in individual cases. Readers will find comprehensive coverage of the
latest developments in surgery radiotherapy androgen deprivation therapy (ADT) chemotherapy
and immunotherapy. The role of the hormonal therapies abiraterone and enzalutamide and
docetaxel-based chemotherapy in castration-resistant prostate cancer and hormone-sensitive
metastatic disease is carefully evaluated. Among the other therapies discussed are LHRH
agonists and antagonists cabazitaxel radium-223 and various novel agents still under
clinical trials. The section on surgical approaches addresses among other topics the use of
robot-assisted radical prostatectomy pelvic lymphadenectomy and the benefits of adjuvant and
neoadjuvant therapy. The current role of external beam radiotherapy alone or in combination
with ADT and brachytherapy for locally advanced disease is reviewed. Management of Advanced
Prostate Cancer will be a valuable resource for practitioners at all levels of expertise.
