Since the 1970s there has been much discussion about the ¿glucoreceptor¿ and ¿substrate site¿
and which of these two is the dominant theory but new findings on the glucose-sensing receptor
have now shed new light on the ¿glucoreceptor theory.¿ This volume reviews recent advances
concerning the glucose-sensing receptor in pancreatic beta-cells.The history of research into
pancreatic beta-cells is long and complex accordingly the first chapters present the history
of this field and explain the hypothesis of insulin secretion mechanisms: ¿glucoreceptor
theory¿. Subsequent chapters examine the function and activity of the glucose-sensing receptor
in pancreatic beta-cells such as identification channel pathway receptor signal and
physiological role. Readers will gain a thorough understanding of the glucose-sensing receptor
and glucose metabolism in pancreatic beta-cells new insights into the pathophysiology of
diabetes and learn about new targets for the treatment of diabetes.
