This book considers and builds on the main propositions regarding body similarity and the
principles of nature versus artifacts in science. It also explores the design (matrix) power of
the human Material Machine Money & Information (3M&I) body with respect to productivity gross
domestic product (GDP). The book begins in 2009 with Weiner's cybernetics and describes
Matsui's theory and dynamism concerning the basic equation of W = ZL and artifact formulation
using matrix methods such as Matsui's matrix equation (Matsui's ME). In his book Fundamentals
and Principles of Artifacts Science: 3M&I-Body System published by Springer in 2016 the
author championed the white-box approach for 3M&I artifacts in contrast to Simon's artificial
approach from 1969. Two principles the Sandwich (waist) and Balancing theories and their
fundamental problems were identified. This book now proposes a third principle: the fractal
harmonic-like structure of the cosmos and life types in space and time. The book further
elaborates on the complexity of the 3M&I system and management in terms of enterprises
economics nature and other applications. Also the domain of nature versus artifacts is
highlighted demonstrating the possibility of a white-box cybernetics-type robot. This fosters
the realization of humanized and harmonic worlds that combine increased happiness and social
productivity in an age increasingly dominated by technology.