This book describes the principles and applications of the spherical crystallization technique
from the standpoint of its inventor. After an introduction on the history of particle design
engineering and nanotechnology the concept of spherical crystallization itself is clearly
explained. Attention then turns to the application of spherical crystallization in
pharmaceutical processes. It is explained how the technique can provide physicochemical
properties suitable for direct tableting of active pharmaceutical ingredients and how it has
enabled the development of a novel particulate design platform from single to complex system.
Subsequent chapters describe the roles of polymeric spherical crystallization in the
preparation of novel microspheres microballoons for drug delivery systems (DDS) and the
development of biocompatible and biodegradable poly(D L-lactide-co-glycolide) (PLGA)
nanospheres. The various applications of PLGA nanospheres composite within oral- pulmonary-
transdermal DDS and cosmetics are fully discussed. Finally future perspectives are presented
on use of the technology in the design and industrial-scale manufacture of new drug delivery
systems highlighting how a continuous pharmaceutical process that meets US Food and Drug
Administration quality requirements should soon be introduced.
