This book summarizes the progress made to functional immobilize G protein-coupled receptors
(GPCRs) through site-specific or orientated recognition in both non-covalent and covalent
manners. The last decade is the dawn of the post-structural biology era for G protein-coupled
receptor research. As an emerging approach for state-of-the-art immobilization this book
discusses efforts to explore the elegance of naturally-occurring biochemical reactions by using
their high specificity and robust reactivity in the complex system such as site-specific
conjugation by covalent recognition between enzymes and their substrates. With the perspective
of protein-drug interactions this book also reviews the applications of protein immobilization
with an emphasis on G protein-coupled receptors in drug discovery and protein-ligand
interaction analysis. In addition the merits opportunities and disadvantages are analyzed for
different immobilization methods and a perspective for future directions is presented. Given
its scope this book appeals to a broad readership particularly researchers engaged in the
field of analytical chemistry bioconjugate chemistry and chemical biology and other related
field as well as teachers of relevant majors in colleges and universities.
