Science is first and foremost an intellectual activity an activity of thought. Therefore how
do we as information scientists respond intellectually to what is happening in the world of
information and knowledge development given the context of new sociocultural and knowledge
landscapes? Information Science as an Interscience poses many challenges both to information
science philosophy and to information practice and only when information science is
understood as an interscience that operates in a multifaceted way will it be able to comply
with these challenges. In the fulfilment of this task it needs to be accompanied by a
philosophical approach that will take it beyond the merely critical and linear approach to
scientific work. For this reason a critical philosophical approach is proposed that will be
characterised by multiple styles of thinking and organised by a compositional inspiration. This
initiative is carried by the conviction that information science will hereby be enabled to make
contributions to significant knowledge inventions that may bring about a better world. Chapters
focus on the rethinking of human thinking our unique ability that enables us to cope with the
world in which we live in terms of the unique science with which we are involved. Subsequent
chapters explore different approaches to the establishment of a new scientific spirit the
demands these developments pose for human thinking for questions of method and the
implications for information science regarding its proposed functioning as a nomad science in
the context of information practice and information work. Final chapters highlight the proposed
responsibility of focusing on information and inventiveness and new styles of information and
knowledge work.