EAN: 9780262045902

HOW NOT TO STUDY A DISEASE - KARL HERRUP GEBUNDEN

An authority on Alzheimer's disease offers a history of past failures and a roadmap that points
us in a new direction in our journey to a cure. For decades  some of our best and brightest
medical scientists have dedicated themselves to finding a cure for Alzheimer's disease. What
happened? Where is the cure? The biggest breakthroughs occurred twenty-five years ago  with
little progress since. In How Not to Study a Disease  neurobiologist Karl Herrup explains why
the Alzheimer's discoveries of the 1990s didn't bear fruit and maps a direction for future
research. Herrup describes the research  explains what's taking so long  and offers an approach
for resetting future research. Herrup offers a unique insider's perspective  describing the red
flags that science ignored in the rush to find a cure. He is unsparing in calling out the
stubbornness  greed  and bad advice that has hamstrung the field  but his final message is a
largely optimistic one. Herrup presents a new and sweeping vision of the field that includes a
redefinition of the disease and a fresh conceptualization of aging and dementia that asks us to
imagine the brain as a series of interconnected neighborhoods. He calls for changes in
virtually every aspect of the Alzheimer's disease research effort  from the drug development
process  to the mechanisms of support for basic research  to the often-overlooked role of the
scientific media  and more. With How Not to Study a Disease  Herrup provides a roadmap that
points us in a new direction in our journey to a cure for Alzheimer's.

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