One approach to organic synthesis is retrosynthetic analysis. With this approach chemists start
with the structures of their target molecules and progressively cut bonds to create simpler
molecules. Reversing this process gives a synthetic route to the target molecule from simpler
starting materials. This disconnection approach to synthesis is now a fundamental part of every
organic synthesis course. Workbook for Organic Synthesis: The Disconnection Approach 2nd
Edition This workbook provides a comprehensive graded set of problems to illustrate and develop
the themes of each of the chapters in the textbook Organic Synthesis: The Disconnection
Approach 2nd Edition. Each problem is followed by a fully explained solution and discussion.
The examples extend the student's experience of the types of molecules being synthesised by
organic chemists and the strategies they employ to control their syntheses. By working through
these examples students will develop their skills in analysing synthetic challenges and build
a toolkit of strategies for planning new syntheses. Examples are drawn from pharmaceuticals
agrochemicals natural products pheromones perfumery and flavouring compounds dyestuffs
monomers and intermediates used in more advanced synthetic work. Reasons for wishing to
synthesise each compound are given. Together the workbook and textbook provide a complete
course in retrosynthetic analysis. Organic Synthesis: The Disconnection Approach 2nd Edition
There are forty chapters in Organic Synthesis: The Disconnection Approach 2nd Edition: those
on the synthesis of given types of molecules alternate with strategy chapters in which the
methods just learnt are placed in a wider context. The synthesis chapters cover many ways of
making each type of molecule starting with simple aromatic and aliphatic compounds with one
functional group and progressing to molecules with many functional groups. The strategy
chapters cover questions of selectivity protection stereochemistry and develop more advanced
thinking via reagents specifically designed for difficult problems. In its second edition
updated examples and techniques are included and illustrated additional material has been added
to take the student to the level required by the sequel Organic Synthesis: Strategy and
Control. Several chapters contain extensive new material based on courses that the authors give
to chemists in the pharmaceutical industry. Workbook for Organic Synthesis: The Disconnection
Approach 2nd edition combined with the main textbook provides a full course in
retrosynthetic analysis for chemistry and biochemistry students and a refresher course for
organic chemists working in industry and academia.
