EAN: 9781461377115

THE FATE OF THE MALE GERM CELL KARTONIERT (TB)

THE FASCINATION The male germ cell is the only cell of the human organism that leaves the body
when it has achieved its final  highly sophisticated structure and properties. The male germ
cell is designed for one purpose only: to reach the female gametes and to fertilize them. The
various stages in the development of the male germ cell are characterized by proliferative
phases  by the recombination of the maternal and paternal chromosomes  and by the
differentiation and development of a specialized transport vehicle  the spermato zoon.
Furthermore  the establishment of a special pool of stem cells  the spermatogonia  guarantees
the continuity of the sperm-generation process from puberty to old age. THE FATE OF THE MALE
GERM CELL The destiny of any individual germ cell is determined by a program that we know only
in fragments. On the one hand every human male is able to produce many billions of germ cells
in his lifetime  yet the chance of any single sperm reaching and fertilizing the female germ
cell is exceedingly rare. A fertility disturbance means that somewhere during the complicated
playing out of the germ cell program mistakes are made  and the program fails. It is still a
fact that more than 50% of men presenting with male factor infertility have to be diagnosed as
idiopathic  largely because of our lack of knowledge and conse quent lack of appropriate
diagnostic tools.

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