A cutting-edge review of the important issues underlying the therapeutic use of nucleic
acid-mediated gene silencing. Topics range from basic methodology and delivery to targeting and
clinical targets. The authors thoroughly explain the latest developments in RNA biology as
well as the underpinnings of RNA interference oligodeoxynucleotide delivery into cells and
strategies for targeting these molecules to accessible regions within the mRNA. They also
provide some examples of how these new therapeutic compounds are being used clinically.
