EAN: 9783031005220

SYNTHESIS LECTURES ON BIOMEDICAL ENGINEERING ...

Recent advances in development of sequencing technology has resulted in a deluge of genomic
data. In order to make sense of this data  there is an urgent need for algorithms for data
processing and quantitative reasoning. An emerging in silico approach  called computational
genomic signatures  addresses this need by representing global species-specific features of
genomes using simple mathematical models. This text introduces the general concept of
computational genomic signatures  and it reviews some of the DNA sequence models which can be
used as computational genomic signatures. The text takes the position that a practical
computational genomic signature consists of both a model and a measure for computing the
distance or similarity between models. Therefore  a discussion of sequence similarity distance
measurement in the context of computational genomic signatures is presented. The remainder of
the text covers various applications of computational genomic signatures in the areas of
metagenomics  phylogenetics and the detection of horizontal gene transfer. Table of Contents:
Genome Signatures  Definition and Background   Other Computational Characterizations as Genome
Signatures   Measuring Distance of Biological Sequences Using Genome Signatures   Applications:
Phylogeny Construction   Applications: Metagenomics   Applications: Horizontal DNA Transfer
Detection

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