EAN: 9783031014505

SYNTHESIS LECTURES ON TISSUE ENGINEERING ARTI...

Cartilage injuries in children and adolescents are increasingly observed  with roughly 20% of
knee injuries in adolescents requiring surgery. In the US alone  costs of osteoarthritis (OA)
are in excess of $65 billion per year (both medical costs and lost wages). Comorbidities are
common with OA and are also costly to manage. Articular cartilage's low friction and high
capacity to bear load makes it critical in the movement of one bone against another  and its
lack of a sustained natural healing response has necessitated a plethora of therapies. Tissue
engineering is an emerging technology at the threshold of translation to clinical use.
Replacement cartilage can be constructed in the laboratory to recapitulate the functional
requirements of native tissues. This book outlines the biomechanical and biochemical
characteristics of articular cartilage in both normal and pathological states  through
development and aging. It also provides a historical perspective of past and current cartilage
treatments and previous tissue engineering efforts. Methods and standards for evaluating the
function of engineered tissues are discussed  and current cartilage products are presented with
an analysis on the United States Food and Drug Administration regulatory pathways that products
must follow to market. This book was written to serve as a reference for researchers seeking to
learn about articular cartilage  for undergraduate and graduate level courses  and as a
compendium of articular cartilage tissue engineering design criteria.Table of Contents: Hyaline
Articular Cartilage   Cartilage Aging and Pathology   In Vitro   Bioreactors   Future
Directions

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