Highlighting 15 selected chiral structures which represent candidate or marketed drugs and
their chemical syntheses the authors acquaint the reader with the fascinating achievements of
synthetic and medicinal chemistry. The book starts with an introduction treating the discovery
and development of a new drug entity. Each of the 15 subsequent chapters presents one of the
target structures and begins with a description of its biological profile as well as any known
molecular mechanisms of action underlining the importance of its structural and stereochemical
features. This section is followed by detailed discussions of synthetic approaches to the
chiral target structure highlighting creative ideas the scaling-up of laboratory methods and
their replacement by efficient modern technologies for large-scale production. Nearly 60
synthetic reactions most of them stereoselective catalytic or biocatalytic as well as chiral
separating methodologies are included in the book. Vitomir Sunjic and Michael J. Parnham
provide an invaluable source of information for scientists in academia and the pharmaceutical
industry who are actively engaged in the interdisciplinary development of new drugs as well as
for advanced students in chemistry and related fields.
