The subject matter of volume 1 of the 2-volumes-handbook focusses on leiomyosarcoma low-grade
and high-grade endometrial sarcoma and undifferentiated uterine sarcoma of the whole female
genitalia. A separate extensive chapter is devoted to the variants of leiomyoma (angio- lipo-
cotyledonoid cellular mitotically active epithelioid and myxoid leiomyoma leiomyoma with
bizarre nuclei) atypical smooth muscle tumors (smooth muscle tumors with uncertain malignant
potential) and disseminated peritoneal leiomyomatosis benign metastasizing leiomyoma and
intravenous leiomyomatosis. Furthermore endometrial stromal tumors - endometrial stromal
nodules endometrial stromal tumor with sex cord-like elements (ESTSCLE) uterine tumor
resembling ovarian sex-cord tumor (UTROSCT) - and similar tumors are described in detail. The
book provides a description at length of the epidemiology etiology pathological anatomy
prognosis diagnosis differential diagnosis imaging and comprehensive therapy of each primary
relapsed and metastasized tumor including surgery chemo- hormone- and radio- and targeted
therapy. Another chapter is devoted to the prevention of subjecting sarcomas to inadequate
surgical therapeutic measures under the assumed diagnosis of leiomyoma and includes a
diagnostic-therapeutic flowchart with a diagnostic score. The book aims to identify and provide
diagnostic and therapeutic guidance. The listed tumor entities also constitute a particular
diagnostic challenge for pathologists that contains numerous pitfalls and difficulties. This
book therefore addresses gynecologists and pathologists in both clinical and private practice
but also surgeons and hemato-oncologists.
