In this volume international experts critically review cutting-edge advances in
neuroprogression research. The relevance of these findings to psychiatric and neurological
disorders is clarified. Potential etiopathological mechanisms of neuroprogression are described
in detail. Special emphasis is placed on the role of the immune system in stress and
stress-related disorders and brain-immune interactions. The epigenetic consequences of adverse
experiences in early childhood which may prelude major psychiatric disorders are also
considered. Recent research has not only provided evidence of neuroprogression in psychiatric
and neurological disorders but has shown that pharmacologic interventions have the potential
to arrest this process. Advances in testing and imaging will lead to timely diagnosis and
earlier treatment. Identification of neurological mechanisms alongside (epi-)genetic
vulnerability markers will create truly personalized treatment programs. This book is a
valuable resource for everyone who wishes to gain insight into the essential features of the
neuroprogressive course of major psychiatric and neurological disorders. In particular
psychiatrists neuroscientists and neurologists ¬ as well as immunologists pharmacologists and
molecular biologists - will find very informative chapters of direct relevance to their field.
