Head and neck squamous cell carcinoma (HNSCC) the sixth most prevalent cancer worldwide
remains a very difficult disease to treat and cure despite intensive investigation into
molecular etiologies and tumor progression pathways. Due to public health efforts encouraging
smoking cessation the overall incidence of HNSCC has decreased in recent years in many
countries. In contrast the incidence of oropharyngeal squamous cell carcinoma (OPSCC) has
increased significantly and this subtype of HNSCC is commonly associated with human
papillomavirus (HPV) infection. Moreover individuals with HPV-positive OPSCC are generally
younger and are frequently non-smokers suggesting that HPV-associated OPSCC represents a
distinct biologic entity.This volume summarizes the spectrum of current HPV-associated OPSCC
research from the fundamental basic science to translational surgery and treatment approaches.
Chapters are contributed by authoritative leaders in the fields of research and clinical care.
Initial chapters address epidemiology behavioral correlates of HPV infection and racial
disparities in oropharyngeal cancer. This is followed by chapters detailing HPV virology with
focus on viral transformation viral replication and host response to viral infection. The
molecular biology of HPV-associated OPSCC is investigated in chapters detailing alterations in
signaling networks and unique mutational profiles of human tumors. Clinical presentation
surgical perspectives and treatment paradigms specific to HPV-associated OPSCC conclude the
volume. This comprehensive volume provides an up-to-date overview of both scientific discovery
and clinical management of this emerging public health problem.
