EAN: 9783319241975

ANTIMICROBIAL PEPTIDES GEBUNDEN

This book focuses on the importance of human antimicrobial peptides (AMP) in keeping the host
healthy and preventing infectious diseases. The first chapters deal with several examples of
the role of AMP in different epithelial organs (skin and wound healing  eye  lung 
genito-urinary tract  gut)  which are exposed to different kinds of infectious microorganisms
and as a result produce different patterns of AMP. Examples of the dysregulation of AMP
expression and function promoting infections are discussed. The capacity of AMP to restrict the
availability of essential metals to bacteria as an efficient antibacterial strategy in
nutritional immunity is discussed in the next chapter. Our current understanding of how vitamin
D  the sunshine vitamin  influences AMP-expression and how this can affect our health is also
addressed. Last but not least  the role of AMP in HIV infection and the immunomodulatory
properties of AMP highlight the diverse facets of AMP in host immunity. AMP's specific
functions  including in fighting multi-resistant bacteria  suggest that they may offer
therapeutic benefits - a question that is discussed in the final chapter.

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