Epigenetic mechanisms (DNA modifications histone alterations and non-coding RNAs) are crucial
for transcriptional regulation and alterations of the physiological epigenome are increasingly
associated with human diseases. During the last decade the emerging field of neuroepigenomics
have started to impact tremendously in areas such learning and memory addiction or
neurodegeneration. This expert volume covers the role of epigenetic molecular mechanism in
regulation of central nervous system's function one of the most exciting areas of contemporary
molecular neuroscience. The book describes the current knowledge on the epigenetic basis of
human disease covering the complete lifespan: from neurodevelopment childhood (Rett Syndrome
Rubinstein-Taybi autism) adolescence (eating disorders drug addiction anxiety) adulthood
(depression schizophrenia amyotrophic lateral sclerosis Huntington's disease) and elderly
(Alzheimer's disease Parkinson's disease).The book also covers the three major players on
neuroepigenomic mechanisms: histones alterations DNA modifications and non-coding RNAs their
roles at the molecular and cellular level and the impact of their alterations on neuronal
function and behavior. Finally a special chapter on state-of-the-art technologies helps the
reader not only to understand epigenetic driven changes in human cognition and diseases but
also the methodology that will help to generate paradigm shifts on our understanding of brain
function and the role of the neuroepigenome in human diseases.
