EAN: 9783319914381

SMALL MOLECULES IN HEMATOLOGY GEBUNDEN

This book  written by respected experts  discusses in detail the latest developments in
targeted therapy for hematologic malignancies using small molecules. It covers a wide range of
small molecules including tyrosine kinase inhibitors  immunomodulatory drugs  the IDH-2
inhibitor enasidenib  the BCL-2 inhibitor venetoclax  and the proteasome inhibitor carfilzomib.
For each molecule  aspects such as the chemical structure  mechanism of action  drug targets 
drug interactions  preclinical studies  clinical trials  treatment applications  and toxicity
are discussed.Extensive research into the molecular mechanisms of cancer has heralded a new age
of targeted therapy. The field of precision cancer therapy is now growing rapidly  and the
advances being made will mean significant changes in the treatment algorithms for cancer
patients. Numerous novel targets that are crucial for the survival of cancer cells can be
attacked by small molecules such as protein tyrosine kinase inhibitors.An accompanying volume
addresses the use of small molecules in oncology  and the two volumes together represent the
third edition of the book originally published under the same title.

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