This book constitutes the proceedings of the 5th InternationalConference on Algorithms for
Computational Biology AlCoB 2018 held in Hong Kong China in June 2018. The 11 full papers
presented together with 1 invited paper were carefully reviewed and selected from 20
submissions. They are organized in the following topical sections: Phylogenetics Sequence
Rearrangement and Analysis Systems Biology and Other Biological Processes.