Provides timely comprehensive coverage of in vivo chemical reactions within live animalsThis
handbook summarizes the interdisciplinary expertise of both chemists and biologists performing
in vivo chemical reactions within live animals. By comparing and contrasting currently
available chemical and biological techniques it serves not just as a collection of the
pioneering work done in animal-based studies but also as a technical guide to help readers
decide which tools are suitable and best for their experimental needs.The Handbook of In Vivo
Chemistry in Mice: From Lab to Living System introduces readers to general information about
live animal experiments and detection methods commonly used for these animal models. It focuses
on chemistry-based techniques to develop selective in vivo targeting methodologies as well as
strategies for in vivo chemistry and drug release. Topics include: currently available mouse
models biocompatible fluorophores radionuclides for radiodiagnosis radiotherapy live animal
imaging techniques such as positron emission tomography (PET) imaging magnetic resonance
imaging (MRI) ultrasound imaging hybrid imaging biocompatible chemical reactions
ligand-directed nucleophilic substitution chemistry biorthogonal prodrug release strategies
and various selective targeting strategies for live animals.-Completely covers current
techniques of in vivo chemistry performed in live animals-Describes general information about
commonly used live animal experiments and detection methods-Focuses on chemistry-based
techniques to develop selective in vivo targeting methodologies as well as strategies for in
vivo chemistry and drug release-Places emphasis on material properties required for the
development of appropriate compounds to be used for imaging and therapeutic purposes in
preclinical applicationsHandbook of In Vivo Chemistry in Mice: From Lab to Living System will
be of great interest to pharmaceutical chemists life scientists and organic chemists. It will
also appeal to those working in the pharmaceutical and biotechnology industries.
