EAN: 9783642541353

PATHOPHYSIOLOGY AND RATIONAL PHARMACOTHERAPY OF...

Ischemie heart disease is still the most frequent cause of death in the western world. There
have been significant achievements in diagnostic procedures as well as in the medical  invasive
and surgiealtreatment ofischemieheart disease inrecent years. A variety ofdrugs are
availablefor the pharmacotherapyofischemieheart disease par ticularly nitrates  ß-blockers  and
calcium-antagonists which are used as mono therapy or in various combinations. However  the
selection of patients for a certain treatment  as weIl as the optimization of an individual
treatment are still largely empirical. On the other hand  the recent advances in experimental
cardiology emphasize the extremely complex and dynamie scenario of ischemic heart disease 
involving endothelial damage  coagulation processes  metabolie and morphologie derangements 
coronary constrictor mechanisms  blood flow redistribution  arrhythmogenesis  contraetile
dysfunction during ischemia and reperfusion  and finally lack or presence of pain perception.
Therefore  it appears desirable to close the gap between experimental and clinical cardiology
and  thus  to provide a pathophysiologieal basis for rational cliniealdecisions with respect to
diagnostic and therapeutic procedures. The idea for this book arose during the preparation of a
seminar series on experi mental cardiology  when I found it diffieultto collect the
pertinentinformation from textbooks of cardiology  physiology  pathology  and pharmacology  as
well as from numerous review and original artieies on specifictopies. I am now very grateful
that expert cliniealand experimental colleagues from around the world have joined me in the
effort to provide a comprehensive textbook on the pathophysiology of myocar dial ischemia and
its rational pharmacotherapy.

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