EAN: 9783658101602

REAL-TIME MONITORING OF CANCER CELL METABOLISM ...

Hamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in
cancer cell lines in real time  particularly: (i) real-time measurements of basic cancer cell
metabolism of different cancer cell lines  (ii) a detailed timeline of the metabolic response
to cisplatin treatment and clear detection of the time span between start of cisplatin
treatment and onset of cell death  which reflects the time required for the underlying
molecular mechanisms of cell fate decision  (iii) direct functional measurement of the
biological activity of a key regulatory protein of cellular metabolism following the kinetic
change in respiration upon SIRT3 overexpression  and (iv) the time-resolved impact of several
organometallic compounds on cell metabolism and cell morphology  including unexpected and not
yet understood highly significant and specific effects on cell-cell interaction and adhesion.

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