EAN: 9783662030219

ASSESSMENT OF THE USE OF SINGLE CYTOCHROME P450...

Metabolic research and especially that which focuses on the monooxygenase cytochrome P450
system has gone through dramatic progressive changes within the last decade. Availability of
highly sophisticated analytical techniques has contributed to increased molecular understanding
of biotransformation pathways. Nowadays designer drugs are computer composable focussing on
metabolic stability. The rapid development of recombinant enzymes has  in many cases  replaced
the intensive work on P450 isolation from naturally occurring sources. Recombinant P450s can be
expressed in cell lines and thus made available for reproducible and constant use addressig a
large number of scientific questions. This book describes the present position of such
research.

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