We examined a sample of 90 individuals that had previously received a course of appropriate
antibiotics for Lyme disease without experiencing full resolution of their symptoms and had
evidence of persistent infection documented by PCR analysis. Mean duration of symptoms was 9.5
years (range 1 - 40 years). The treatment was adapted to the individual case according to
clinical response. Long term antibiotic therapy was initiated and patients were treated
continuously for at least 6 months in some cases several years of intermittent therapy was
administered. About 38.8% of the patients experienced full remission of symptoms while about
56.7% reported a significant improvement 5.6% of patients were deemed refractory to therapy.
Therapeutic modalities are discussed in detail.
