EAN: 9780128008379

VIRUS AS POPULATIONS - ESTEBAN DOMINGO KARTONIE...

Virus as Populations: Composition  Complexity  Dynamics  and Biological Implications explains
fundamental concepts that arise from regarding viruses as complex populations when replicating
in infected hosts. Fundamental phenomena in virus behavior  such as adaptation to changing
environments  capacity to produce disease  probability to be transmitted or response to
treatment  depend on virus population numbers and in the variations of such population numbers.
Concepts such as quasispecies dynamics  mutations rates  viral fitness  the effect of
bottleneck events  population numbers in virus transmission and disease emergence  new
antiviral strategies such as lethal mutagenesis  and extensions of population heterogeneity to
nonviral systems are included. These main concepts of the book are framed in recent
observations on general virus diversity derived from metagenomic studies  and current views on
the origin of viruses and the role of viruses in the evolution of the biosphere.

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