Multiple sclerosis (MS) is the most common disabling neurological disease of young adults. More
than 2.3 million people are affected by MS worldwide. Symptoms can vary widely depending on
the localization and amount of the damage induced by combined inflammatory demyelinating and
neurodegenerative processes. Although a cure for MS does not currently exist therapies can
help treat MS attacks attenuate disease activity reduce progress of the disease and manage
symptoms. Translational Neuroimmunology in Multiple Sclerosis provides an overview of recent
findings and knowledge of the neuroimmunology of multiple sclerosis from experimental models
and the human disease to the translation of this research to immunotherapeutic strategies.
Chapters describe genetic and environmental factors underlying the disease pathogenesis of MS
as a basis for development of immunotherapies immunological markers of disease activity
pharmacogenetics and responses to therapy. Immunomodulatory therapies currently in practice
and future therapeutic strategies on the horizon-such as neuroprotective strategies stem cells
and repair promotion-are discussed. Contributed by renowned leaders in the field this
cross-disciplinary volume is a great resource for basic scientists and clinical practitioners
in neuroscience neurology immunology pharmacology and in-drug development.
