EAN: 9781441967510

ENVIRONMENTAL FACTORS GENES AND THE DEVELOPMENT...

Cancer is a complex disease. Only 5-10% of human cancers are hereditary in nature. Many of us
think of environmental agents when we think of carcinogens. The environment includes all that
surrounds us  and environmental influences include not only chemical  physical and biological
toxicants  but also diet and lifestyle. In this broadest sense  the environment contributes
substantially in the development of human cancer. This book will describe how environment
contributes to malignant transformation leading to profound changes in the genetic and
signaling networks that control the functioning of the cell. It will critically discuss the
understanding of the effects of environment on the development  progression and metastasis of
cancer with current knowledge of the signaling networks that support functioning of transformed
human cells. Genes and environmental factors that influence the origins of cancer are not
necessarily the same as those that contribute to its progression and metastasis. Susceptibility
gene variants for each specific cancer are being identified with emerging evidence of
gene-environment interaction. Gene-environment interactions will be discussed through each
specific cancer-based approach to address the question of how genetic variations can influence
susceptibility to the individual type of cancer. It will also highlight and summarize
epigenetic changes that increase the risk for susceptibility to a particular type of cancer 
particularly in the presence of specific environmental factors. Thus  this book will contain
chapters from the world's experts focused on the current evidences that support the role of
environment in the cancer etiology and in the growth of malignant lesions  and discuss who may
be susceptible to environmental influences.

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