EAN: 9781441971296

MOLECULAR DEFECTS IN CARDIOVASCULAR DISEASE GEB...

Molecular Defects in Cardiovascular Disease provides an in-depth discussion of the molecular
mechanisms underlying the genesis of cardiovascular defects and the implications this has on
current and emerging targeted therapeutics. Divided into three sections  this book covers the
scientific foundations of our present understanding as well as the array of clinical
manifestations and their treatment. The first section covers Molecular Mechanisms of Heart
Disease  with discussion of the development of cardiovascular dysfunction. The remaining two
sections provide a more clinical focus. The second  Cardiac Hypertrophy and Heart Failure deals
with metabolic derangements  Ca2+ handling  and subcellular remodeling. It illustrates the wide
variety of molecular defects which may serve as targets associated with the transition from
cardiac hypertrophy to advanced heart failure. The third section  Hypertension and Diabetes 
provides molecular rationale for the pathogenesis of hypertension and diabetic cardiomyopathy 
as well as highlighting the importance of hormones toward this end. A necessary resource for
clinicians and researchers  this book elucidates the experimental basis of the practice of
cardiology. It is the culmination of our advances in the understanding of cardiovascular
molecular biology and a blueprint for the efficacious use of targeted therapies.

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