EAN: 9781441999108

INSULIN RESISTANCE AND CANCER GEBUNDEN

This book reviews the epidemiological associations between insulin resistance and cancer. This
is followed by reviews of animal models which support this relationship and provide insight
into potential mechanisms. Several chapters then provide detailed examination of the cellular
and molecular changes characterizing the insulin resistant state  such as hyperinsulinemia 
abnormal metabolism and hormone signaling  and how these interact with various tumor
characteristics. For example some tumors present increased quantities of the fetal form of the
insulin receptor  unique regulation of oxidative (Krebs' cycle) metabolism (Warburg effect)  as
well as mutations in various relevant signaling pathways. Finally  the clinical implications of
these data are integrated with considerations of insulin sensitization and potential metabolic
interventions to prevent and treat cancer. It should be noted that while a number of cancers
are associated with obesity the authors here have focused primarily on breast cancer as a key
and significant model.

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