EAN: 9781461439028

ADENOSINE GEBUNDEN

Homeostasis of key metabolites and metabolic health affects all bodily systems. Not
surprisingly  altered metabolic function is associated with a wide spectrum of dysfunctions in
the central nervous system - including developmental disorders  acute nervous system injury 
and neurodegenerative disorders. Accordingly  metabolism-based therapies offer significant
promise as new category of treatment options designed to limit  delay or reverse the disease
process by reconstructing homeostatic functions. Increasingly it is appreciated that restoring
metabolic health could promote normal nervous system activity  and improve behavior and
cognition. Adenosine: A Key Link Between Metabolism and Central Nervous System Activity
focusses on diverse aspects of adenosine  an evolutionarily conserved homeostatic bioenergetic
regulator in the central nervous system. Because of its interrelationship with ATP (adenosine
triphosphate)  adenosine is integral to cell metabolism. At the same time  adenosine influences
neuronal activity directly via receptors  and is involved in biochemical processes related to
gene expression. Thus  adenosine is uniquely placed as a reciprocal and rapid link between
changes in metabolism and changes in neuronal activity  and  on a longer time scale  to changes
in gene expression and long term changes in cell function. Leaders in the field feature basic
research on adenosine at the cellular level in the central nervous system  and relate these
findings to its recognized potential in diverse acute and chronic disorders. This comprehensive
overview of adenosine also highlights emerging adenosine-based treatments and associated
opportunities for central nervous system disorders.

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