EAN: 9781493988907

SYSTEMS CHEMICAL BIOLOGY GEBUNDEN

This volume explores the latest available wet-lab techniques and computational methods to study
in-cell small-molecule behavior and interactions with their targets. The chapters in this book
discuss topics such as disease-relevant models for chemical biology studies  target engagement
using cellular thermal shift assay or bioluminescence resonance energy transfer  visualization
of bio-active small molecules Raman microscopy  (phospho-)proteomics and transcriptomics for
mode-of-action studies  CRISPR Cas9-based chemogenomic profiling in mammalian cells  predicting
drug interactions using computational approaches  comparison of compound-induced profiles using
high-content imaging or cancer cell line panels and web-based tools for polypharmacology
prediction. Written in the highly successful Methods in Molecular Biology series format 
chapters include introductions to their respective topics  lists of the necessary materials and
reagents  step-by-step  readily reproducible laboratory protocols  and tips on troubleshooting
and avoiding known pitfalls. Cutting-edge and thorough  Systems Chemical Biology: Methods and
Protocols is a valuable resource for novice or expert scientists and researchers trying to
initiate or continue their chemical biology studies at a systems level.

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