Molecular Mechanisms of Inflammation Induction Resolution and Escape by Helicobacter pylori Gebunden

This book focuses on immune reactions and interactions of humans with Helicobacter pylori - a human pathogen connected to gastritis peptic ulcers and even gastric cancer. With nearly half of the world's population colonized it has been characterized as one of the most successful pathogens for more than 100 000 years of co-evolution with its host. The respective chapters discuss not only how H. pylori infection is considered a paradigm for persistent bacterial infection and chronic inflammation but also how the infection might be connected to host protection against gastro-esophageal disease s asthma and other allergic disease manifestations. Readers will gain essential insights into the roles of specific factors in the immune response and learn about the impact of genetic polymorphisms on the risk of gastric carcinogenesis. In addition the book discusses the strategies used by this bacterium which allow it to colonize specific sites in the stomach interact with the microbiome evade immune surveillance and undermine the resolution of inflammation during persistent infection. This volume presents a concise summary of recent advances in the areas of induction resolution and escape of inflammation innate and adaptive immunity gastric disease development as well as treatment and vaccination against H. pylori. Accordingly it offers a valuable asset for scientists and clinicians alike.