EAN: 9783030151379

MOLECULAR MECHANISMS OF INFLAMMATION INDUCTION ...

This book focuses on immune reactions and interactions of humans with Helicobacter pylori - a
human pathogen connected to gastritis  peptic ulcers and even gastric cancer. With nearly half
of the world's population colonized  it has been characterized as one of the most successful
pathogens for more than 100 000 years of co-evolution with its host. The respective chapters
discuss not only how H. pylori infection is considered a paradigm for persistent bacterial
infection and chronic inflammation  but also how the infection might be connected to host
protection against gastro-esophageal diseases  asthma  and other allergic disease
manifestations. Readers will gain essential insights into the roles of specific factors in the
immune response and learn about the impact of genetic polymorphisms on the risk of gastric
carcinogenesis. In addition  the book discusses the strategies used by this bacterium  which
allow it to colonize specific sites in the stomach  interact with the microbiome  evade immune
surveillance and undermine the resolution of inflammation during persistent infection. This
volume presents a concise summary of recent advances in the areas of induction  resolution and
escape of inflammation  innate and adaptive immunity  gastric disease development  as well as
treatment and vaccination against H. pylori. Accordingly  it offers a valuable asset for
scientists and clinicians alike.

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