At present most intracranial gliomas are considered incurable with current treatment strategies
and the search for new modalities that may effectively control tumor growth continues. The
chapters in this volume describe basic principles and therapeutic possibilities of several
innovative techniques including photodynamic therapy laser-induced interstitial thermotherapy
stereotactic cryodestruction high-intensity focused ultrasound ablation boron neutron capture
therapy proton and carbon ion irradiation targeted therapy immunotherapy gene therapy
local chemotherapy and alternating electric fields therapy. Potential applications of
extracellular vesicles and nanotechnology for management of gliomas are highlighted as well.
Many of these methods have already demonstrated antitumor efficacy in clinical testing whereas
others are still under development. The materials presented in this book are mainly directed at
clinicians treating patients with brain tumors as well as clinical and basic researchers
working in the field of neuro-oncology.
