EAN: 9783319088303

REFERENCE SERIES IN BIOMEDICAL ENGINEERING CE...

This reference work presents the origins of cells for tissue engineering and regeneration 
including primary cells  tissue-specific stem cells  pluripotent stem cells and
trans-differentiated or reprogrammed cells. There is particular emphasis on current
understanding of tissue regeneration based on embryology and evolution studies  including
mechanisms of amphibian regeneration. The book covers the use of autologous versus allogeneic
cell sources  as well as various procedures used for cell isolation and cell pre-conditioning 
such as cell sorting  biochemical and biophysical pre-conditioning  transfection and
aggregation. It also presents cell modulation using growth factors  molecular factors 
epigenetic approaches  changes in biophysical environment  cellular co-culture and other
elements of the cellular microenvironment. The pathways of cell delivery are discussed with
respect to specific clinical situations  including delivery of ex vivo manipulated cells via
local and systemic routes  as well as activation and migration of endogenous reservoirs of
reparative cells. The volume concludes with an in-depth discussion of the tracking of cells in
vivo and their various regenerative activities inside the body  including differentiation  new
tissue formation and actions on other cells by direct cell-to-cell communication and by
secretion of biomolecules.

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